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Biology of Life Span: A Quantitative Approach
More books in the category:
Biology of Aging
by: Leonid A. Gavrilov, Natalia S. Gavrilova
Topics include: oncological characteristics, entire age interval, life span distribution, heterogeneous population model, life span indexes, mortality phenomena, life span limit, blood cholesterol content, lifetime variability, vitally important structures, demographic life tables, nonspecific vulnerability, years ordinate, life span values, days ordinate, greater life span, laboratory drosophila, biological mortality, determination hypothesis, human life tables, span distributions, calory intake, mean life span, binomial law, maximal age
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First Sentence:
If one analyses the contemporary scientific literature on life span, the exceptional variety of the existing approaches is particularly striking….
Table of Contents
Preface, 1
Acknowledgments, 3
Chapter 1. Introduction
1.1 Why is it necessary to study life span? 5
1.2 Short history of the subject, 10
1.3 The present state of the discipline, 15
Chapter 2. Individual Differences in Lifetime
2.1 Where should the study of life span begin? 21
2.2 Individual differences - the key issue in the biology of life span, 22
2.3 The nature of variability in lifetimes, 31
2.4 In search of the life span distribution law, 39
2.5 The Gompertz-Makeham law, 50
2.6 Unresolved issues and problems, 61
Chapter 3. The Human Life Span, 64
3.1 Specific questions connected with research into the human life span, 64
3.2 Regularities of human mortality, 67
3.3 The biological characteristics of the human life span, 72
3.4 The epidemiological approach to studying the biology of the human life span, 86
3.5 Prospects for human life span extension, 106
Chapter 4. Species-specific Life Span, 117
4.1 Review of ideas about species-specific life span, 117
4.2 Is there a species-specific life span limit? 125
4.3 The concept of species-specific life span invariants, 132
4.4 The Strehler-Mildvan correlation, 141
4.5 The compensation effect of mortality, 148
Chapter 5, The Search for the Mechanisms Which Determine Life Span, 157
5.1 A self-destructive program or wear and tear? 157
5.2 Analysis of inter-species differences in the duration of life, 165
5.3 Analysis of intra-species differences in the duration of life, 175
5.4. Analysis of sex differences in lifetimes, 182
5.5 Experiments in life extension, 205
5.6 The limit of cell division: the key to the mechanism which determines life span? 210
5.7 Reliability theory: the methodological foundation for research into the mechanisms which determine life span, 225
Chapter 6. Mathematical Models of Life Span, 232
6.1 Introduction, 232
6.2 The need for a critical attitude to mathematical models of life span, 235
6.3 Limiting distributions of the life spans of biological systems, 240
6.4 The model of the avalanche-like destruction of an organism in natural aging, 246
6.5 The model of a multiply redundant system saturated with defects, 252
6.6 The model of a redundant system with an arbitrary number of defects, 258
6.7 The heterogenous population model, 264
6.8 The model of accumulation of defects with constant intensity of the flow of damage, 272
6.9 The problem of the diversity of causes of death and their interaction, 276
6.10 Concluding remarks, 285
Conclusion, 290
Appendix 1
List of published animal life tables, 293
Appendix 2
Table A: Features which show a positive correlation with the life span of organisms, 310
Table B: Features which show a negative correlation with the life span of organisms, 317
Table C: Features which show a weak correlation with the life span of organisms, 322
References, 326
Subject Index, 367
Reviews:
Nature' wrote: "Good new book on ageing"
The journal 'Nature' (1991, vol.352, 29 August, pp.767-768) published a review of this book including the following comment:
"Good new book on ageing".
The published review was written by Dr. Thomas B.L.Kirkwood, Ph.D. who was the head of the Laboratory of Mathematical Biology, National Institute for Medical Research (London, United Kingdom) at that time.
Published reviews of the book "The Biology of Life Span"
This book is selected and cited by Encyclopedia Britannica as recommended reference on longevity topic. The book was also reviewed by Nature (1991, 352: 767), British Medical Journal (1992, 305: 431), BioEssays (1993, 15: 359), Quarterly Review of Biology (1993, 68: 92), Population Studies (1992, 46: 366), Population and Development Review (1992, 18: 555 and 1998, 24: 381), Am.J.Epidemiology (1994, 139: 231), Experimental Gerontology (1992, 27: 251), Gerontologist (1991, 31: 707), Human Biology (1992, 64: 630), J.Epidemiology & Community Health (1992, 46: 630), J.Institute of Actuaries (1992, 119: 379), Age and Ageing (1992, 21: 386), Ageing and Society (1991, 11: 509), Archives of Gerontology and Geriatrics (1992, 15: 192), Educational Gerontology (1993, 19: 92), Free Radical Biology & Medicine (1992, 12: 331).