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Mitochondrial Free Radical Theory of Aging
More books in the category:
Biology of Aging
by: Aubrey D.N.J. DeGrey
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The vast complexity of organismal degeneration with age has too often intimidated gerontologists into over-cautious interpretation of their results. Therefore, theories of mammalian aging have been too open and preliminary to underpin the design of medical interventions. This book breaks new ground in the effort to overcome that inertia, by providing a highly detailed and experimentally well-founded model of mammalian aging, together with analysis of the ways in which that model may be exploited to influence the rate of aging. It will benefit biologists, clinicians and the scientifically-minded laypersons alike, by giving a robust conceptual structure to compare with ongoing experimental and medical findings.
Table of Contents
Introduction
An Introduction to Mitochondria
An Introduction to Free Radicals
An Introduction to Lipid Metabolism
A Descriptive Introduction to Human Aging
History of the Mitochondrial Free Radical Theory of Aging, 1954-1995
The Status of Gerontological Theory in 1995
The Search for How Mutant mtDNA Is Amplified
The Search for How So Few Anaerobic Cells Cause So Much Oxidative Stress
Frequently-Asked Questions
A Challenge from Textbook Bioenergetics and Free Radical Chemistry
Some Testable Predictions of MiFRA
Reviews:
A work of genius and 5000 calories per page
Don't let the small size fool you - this is very dense reading. For anyone who has an good understanding of biology, it will still take you awhile to get through it. I loved it, especially the theories on why the mitochondria developed like they did, what works to protect mitochondria, and what we can eventually do to make mtRNA irrelevant (which might be a good thing).
A fascinating book with some quite remarkable insights
I have to say I'm thoroughly impressed with this book. It is not only a meticulous, highly readable review of a lot of otherwise tough to follow scientific literature, but it is also an exploration of ideas and interpretations that, as far as I can tell, are totally new. I was also surprised at how understandable and readable this book was -- the author is obviously a great and compelling writer which is certainly not true of all scientists. It's an extremely rare find. I also note that Mr. de Grey's ideas have already been noted and well received by the scientific community -- his name is mentioned favorably in Medline abstracts of peer-reviewed scientific studies by world authorities on mitochondrial genetics, aging and species life extension. "The de Grey hypothesis". If you are interested in this area, you need to buy this book. I don't think there's a better review of this area anywhere, and the freshness of some of the author's ideas -- all based on published evidence -- is very pleasing.