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[A1CR]

This is an important CR study from March 2004. It found that women who were hospitalized with anorexia nervosa (AN) -- notably, anorexia nervosa is characterized by CRHN (caloric restriction with horrible nutrition) -- had a dramatically lower incident of breast cancer later in life. The study's conclusion is "severe caloric restriction in humans may confer protection from invasive breast cancer." This finding is particularly interesting since it occurred despite the notoriously poor dietary habits of AN (adequete nutrition) sufferers.

Animal studies using rodents have demonstrated that CR is extremely effective against cancers. The paper appears to have much for many important implications for CRONies: IGF-1 related factors, growth factors and live human beings that pathologically but intentionally lose, not loose, weight.

Please note: It is a retrospective cohort study, not a prospective study. Perhaps, randomized control studies are impossible for CR.

JAMA, March 10, 2004—Vol 291, No. 10
Caloric Restriction and Incidence of Breast Cancer
Karin B. Michels, Anders Ekbomn

Context:
Restricting caloric intake is one of the most effective ways to extend lifespan
and to reduce spontaneous tumor occurrence in experimental animals, but whether
similar associations hold in humans has not been appropriately studied....

Design, Setting, and Participants:
Retrospective cohort study ....
Participants were 7303 Swedish women hos-pitalized
for anorexia nervosa prior to age 40 years between 1965 and 1998. Women
were excluded (n=31) if they were diagnosed with cancer prior to their first discharge
from hospitalization for anorexia nervosa....

Results:
Compared with the Swedish general population, women hospitalized for
anorexia nervosa prior to age 40 years had a 53% (95% confidence interval [CI],
3%-81%) lower incidence of breast cancer; nulliparous women with anorexia ner-vosa
had a 23% (95% CI, 79% higher to 75% lower) lower incidence, and parous
women with anorexia nervosa had a 76% (95% CI, 13%-97%) lower incidence.

Conlusions:
Severe caloric restriction in humans may confer protection from inva-sive
breast cancer. Low caloric intake prior to first birth followed by a subsequent
pregnancy appears to be associated with an even more pronounced reduction in
risk.