|
|
| Author |
Message |
A1CR
Site Admin
Joined: 18 Jan 2006
Posts: 559
|
 Posted: Fri Feb 17, 2006 4:47 am Post subject: Study links Autoimmune Disease to Hypoglycemia |
 |
|
[posted on behalf of MR; 07 Feb 2001]
On 7 Feb 2001
A CRONie mentioned:
>Here is an interesting release I found.I was labled as
>a hypoglycemic several years ago before my diagnosis
>of auoimmunity. There appears to be a connection to
>carbohydrate consumption and autoimmunity.
MR responds:
CRONie, this is an extremely interesting study -- thanks for finding it.
However, (1) it'd be helpful if, in future, whenever you cite an
article, you give the URL of the website, the bibliographic info on the
book the PMID on the study, etc. This has led to much frustration and
confusion in the past.
Here is the abstract:
| Quote: |
Proc Natl Acad Sci U S A 2001 Jan 30;98(3):1142-1147
Genetic remodeling of protein glycosylation in vivo induces autoimmune disease.
Chui D, Sellakumar G, Green RS, Sutton-Smith M, McQuistan T, Marek KW,
Morris HR, Dell A, Marth JD
.... Protein glycosylation in the Golgi apparatus produces structural
variation at the cell surface and contributes to immune
self-recognition. Altered protein glycosylation and antibodies that
recognize endogenous glycans have been associated with various
autoimmune syndromes, with the possibility that such abnormalities may
reflect genetic defects in glycan formation.
We show that mutation of a single gene, encoding alpha-mannosidase II,
which regulates the hybrid to complex branching pattern of extracellular
asparagine (N)-linked oligosaccharide chains (N-glycans), results
in a systemic autoimmune disease similar to human systemic lupus erythematosus.
... Lymphocyte development, abundance, and activation parameters are
normal; however, serum immunoglobulins are increased and kidney function
progressively falters as a disorder consistent with lupus nephritis
develops. Autoantibody reactivity and circulating immune complexes are
induced, and anti-nuclear antibodies exhibit reactivity toward histone,
Sm antigen, and DNA. These findings reveal a genetic cause of autoimmune
disease provoked by a defect in the pathway of protein N-glycosylation.
PMID: 11158608 |
Note that, from both the news study you cite and the abstract, that this
study has nothing to do with hypoglycemia or carbohydrate fuel
metabolism per se, but abour abnormal synthesis of cell surface
proteoglycans, which are used by the body as receptors and immune
markers.
>but this new research suggests that lupus and other
>autoimmune diseases involve abnormalities in the way
>the body produces carbohydrates.
>
>Scientists have linked lupus-like symptoms in mice
>with a mutation in a gene that helps form
>carbohydrates that dwell on cell surfaces. They
>believe it is possible the mutation alters
>cell-surface carbohydrates to the point where the
>immune system believes they are foreign and attacks.
>
>In the new study, Marth's team bred mice with a
>mutation in a gene involved in forming carbohydrate
>structures on cell surfaces. The investigators found
>the defect triggered abnormalities in the animals'
>cell-surface carbohydrates and, more importantly,
>lupus-like damage. Marth said the disease his team
>produced is closer to lupus than in any other mouse
>model.
>
>researchers have found that some patients with
>autoimmune disorders have abnormalities in the way
>their body processes carbohydrates, Marth pointed out.
>
>According to Marth, research shows that "what we put
>into the body"--even dietary changes--can alter
>cell-surface carbohydrates.
Great stuff! And a tie-in with lectins ...
-MR |
|
| Back to top |
|
 |
|
|
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum
|
|
|
Search
Log in
