cron-web.org

[A1CR]

CRON4healthyfuture points to a study by Spindler and his associates where they made microarray gene expression analysis in mice that are long-lived either due to a genetically-induced low level of IGF-1 (dwarfism) or due to CR. Some of the gene expression changes they observed overlapped between the two groups, and some changes were disjoint. They characterize the apparent roles of the overlapping changes and they are a laundry list of factors that are thought to influence aging -- e.g. cellular proliferation, apoptosis, protein turnover, oxidative metabolism, etc.

These are exciting times in the field of aging research. Using techniques like gene microarray analysis, it looks like scientists are beginning to gain real insights into the mechanism underlying the aging process, and how CR slows it down.

[posted on behalf of CRON4healthylife; 2004-03-25]

Spindler characterizes "Low IGF-1 dwarfism" and CR; Finds they are similiar

Spindler continues to explore CR in relation to low IGF-1, and finds
that they both affect a similiar population of genes.

Because both of these interventions can additively extend lifespan,
this population of genes that they additively effect could hold the
key to understanding what processes can be associated with aging.

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Ab
stract&list_uids=15039484
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"Disrupted growth hormone/insulin-like growth factor-1 signaling (DF)
and caloric restriction (CR) extend lifespan and delay the onset of
age-related diseases in rodents. In combination, these interventions
additively extend lifespan. To investigate the molecular basis for
these effects, we performed genome-wide, microarray expression
analysis of liver from homozygous and heterozygous Ames dwarf mice
fed ad libitum or CR. CR and DF additively affected a group of 95
genes. Individually and together, DF and CR independently affected
the expression of 212 and 77 genes, respectively. These results
indicate that DF and CR affect overlapping sets of genes, and
additively affect a subset of genes. Together, the interventions
produced changes in gene expression consistent with increased
insulin, glucagon and catecholamine sensitivity, gluconeogenesis,
protein turnover, lipid beta-oxidation, apoptosis, and xenobiotic and
oxidant metabolism; and decreased cell proliferation, lipid and
cholesterol synthesis, and chaperone expression. These data suggest
that the additive effects of DF and CR on lifespan develop from their
additive effects on the level of expression of some genes, and from
their independent effects on other genes. ..."