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[A1CR]

[posted of behalf of CRON4healthyfuture 2006-02-16]

No big surprises here, but, the important advance is that this transitions man's understanding of the phenomenology of food deprivation from serological correlates of behavior to neurophysiologic correlates of behavior.

In other words, the big story was that low leptin induces "hyperactivity".

This shows that when you are "in the brain", neuropeptide Y, a representative "eating promoting neurotransmitter, can reduce sleep and increase eating.

So, serological parameters that induce hyperactivity can be thought to promote neurophysiologic changes in the brain that are manifested in the results of this study.

There has been some recent controversy as to the comprehensiveness of neuropeptide Y's contribution to feeding behavior, but, at the moment, Neuropeptide Y still "looms large" in any discussion of "feeding behavior".

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Central Administration of Neuropeptide Y Induces Wakefulness in Rats

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http://ajpregu.physiology.org/cgi/content/abstract/00919.2005v1

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"Intracerebroventricular and lateral hypothalamic administration of NPY suppressed non rapid-eye-movement sleep and rapid-eye-movement sleep in rats during the first hour after the injection and also induced changes in EEG delta power spectra. Neuropeptide Y stimulated food intake in the first hour after both routes of administration. Data are consistent with the hypothesis that NPY has a role in the integration of feeding, metabolism and sleep regulation."