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Calorie Restriction with Optimum Nutrition Forum
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A1CR
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Joined: 18 Jan 2006
Posts: 559
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 Posted: Tue Mar 07, 2006 5:09 am Post subject: Targeting energy metabolism in Huntington's disease |
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Huntington's disease is rare. However, studying how it may be corrected with CR may be useful for examining how CR helps brain functions, in general.
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| Finding an effective treatment for Huntington's disease has been difficult. Initially, this lack reflected a dearth of animal models, genomic technology, and promising therapies. Even when treatments were tested, the clinical trials have been major undertakings because Huntington's disease is rare (about 1 per 10 000 in North America and Europe) and has a variable age of onset and slow rate of progression. The first animal models were based on the observation that excitotoxins caused a Huntington-like distribution of death of striatal neurons in rodents. After the discovery of the HD gene for Huntington's disease a decade ago, these animal models of acute neuronal cell-death were supplemented by various transgenic animal models that have more accurately replicated the progressive time course of this disease[...]. |
Targeting energy metabolism in Huntington's disease.
Lancet. 2004 Jul 24-30;364(9431):312-3. No abstract available.
PMID: 15276373
An intro to Huntington's disease is here:
http://en.wikipedia.org/wiki/Huntington%27s_disease |
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