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[A1CR]

[posted on behalf of CRON4healthyfuture]

High intracellular Vitamin C fries DNA in an "unconventional" way...

These are really high concentrations of vitamin C, but, the principle if something to consider.

What is interesting is that all of that vitamin C can act as an electron sink that reduces Iron and effectively "recharges" Iron in a vicious cycle of pro-oxidation.

In the course of this, it generates a DNA lesion that is not routinely assayed for in lab work investigating "DNA damage". In other words, it can cook your DNA in a way that flies "under the radar".

They say that cancer cells may be susceptible to this. In fact, they suggest a synergistic administration of DHA (n-3 fish oil component) and Vitamin C to "fry" cancer cells using this method.

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http://dx.doi.org/10.1016/j.freeradbiomed.2006.02.003

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"The presence of a high concentration of ascorbate (30 mM), compared to the absence of ascorbate in cells, when exposed to H2O2 (200 ìM), resulted in a remarkable sensitization of oh5dCyd from 2.7 ± 0.6 to 40.8 ± 6.1 lesions /106 dCyd (15-fold). In contrast, the level of oxo8dGuo increased from 8.4 ± 0.4 to 12.1 ± 0.5 lesions/106 dGuo (50%)."