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[A1CR]

[posted on behalf of CRON4healthyfuture]

Granted, it's a long fast, 48 hours.....but, Figure 5 in the Free Full-Text gets at the issue.

These researchers are delving into the complexity of tissue level expression of IGF-1, a truly mysterious part of the story that is still being worked out. Some tissues maintain local IGF-1 production irrespective of acute variations in serum IGF-1, while other tissues seem to "take their cue". And then some tissues, like muscle, stick IGFBP-5 out there.....

Very complicated....for the moment, I would watch serum IGF-1 more than anything.

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http://endo.endojournals.org/cgi/rapidpdf/en.2005-0742v1

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"Fasting of female B6 and female C3H mice reduced serum IGF-I (Figure 4A) and liver IGF-I mRNA levels (Figure 4B and 4C)."

"Although fasting reduced serum IGF-I levels in the male mice of both strains, serum IGF-I levels were higher in fasted male C3H than in fasted
male B6 mice (Figure 5A). However, fasting did not produce the expected decline in liver IGF-I in male mice of either strain (Figure 5B and 5C)."