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CRON4healthyfuture
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 Posted: Sat Mar 18, 2006 12:27 am Post subject: Hydrogen peroxide from mitochondria affects signalling |
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Most people tend to think of hydrogen peroxide from the mitochondria, H2O2, as causing damage, and that this damage leads to aging.
The actual effects of hydrogen peroxide may end up causing damage through a more indirect way. It turns out that hydrogen peroxide from the mitochondria can affect the function of many receptors in ways that may make receptors abnormally active.
In this context, it could be that this receptor dysregulation could promote the constellation of pathologies known as aging.
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| "This study describes the use of redox-engineered cell lines to identify PTEN as sensitive to oxidative inactivation by mitochondrial H2O2. Increases in the steady state production of mitochondrial derived H2O2, as a result of manganese superoxide dismutase (Sod2) overexpression, led to PTEN oxidation that was reversed by the coexpression of the H2O2-detoxifying enzyme catalase. The accumulation of an oxidized inactive fraction of PTEN favored the formation of phosphatidylinositol 3,4,5-triphosphate at the plasma membrane, resulting in increased activation of Akt and modulation of its downstream targets." - J. Biol. Chem., Vol. 280, Issue 17, 16916-16924, April 29, 2005 |
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