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Calorie Restriction with Optimum Nutrition Forum
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CRON4healthyfuture
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 Posted: Sat Mar 25, 2006 1:06 am Post subject: Mitochondria of vascular endothelium for signaling, not ATP? |
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Fascinating new paper in the Proceedings of the National Academy of Sciences. It turns out that mitochondria in the vascular endothelium are strategically positioned to gauge local oxygen concentration, and transduce that information into signaling mediators.
The importance for aging science is going to be seen with the observation that the protein AMPK is activated in the process of this signaling. Obviously, this protein sits at a very important point in the intracellular confluence of metabolic information.
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"At higher O2 concentrations (1-3%) NO facilitates the production of mitochondrial reactive oxygen species. This production activates the AMP-activated protein kinase by a mechanism independent of nucleotide concentrations. Thus, the primary role of mitochondria in vascular endothelial cells may not be to generate ATP but, under the control of NO, to act as signaling organelles using either O2 or O2-derived species as signaling molecules. Diversion of O2 away from endothelial cell mitochondria by NO might also facilitate oxygenation of vascular smooth muscle cells." - Proceedings of the National Academy of Sciences Published online before print March 24, 2006
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