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[CRON4healthyfuture]

This is an interesting new paper from one of the journals produced by the American Physiological Society. The authors discuss how all of the known "free radicals" interact with one another on multiple levels.

Sometimes they mesh to produce a sad song that ends in cell death, but other times they produce a stirring melody.

Their equation with "bad outcomes" is something that has been driven by commercial interests. If the body uses them as a signal, then their elevation would naturally be associated with an "alarm" that can end in "unhappy outcomes". But their total elimination will also generate "alarm", or alternatively sheer dysregulation, both of which could similiarly lead to an "unhappy outcome".

This is particularly important for the more ambitious wings of the experimental physiology and biogerontology communities that want to "engineer" improvements to life. The core "grammar" of life is imbued with radicals. If you want to eliminate radicals, you are going to need to write a new genome complete with a new physiology that works.

Not saying that it can't be done, but, I think that is above and beyond the current capabilities of geneticists.

What may be something interesting that needs to be looked into is the possibility that "really bad" radicals could be inactivated by "not so bad" radicals. Perhaps you could "trade up" for physiologic benefit?

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