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CRON4healthyfuture
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 Posted: Thu Apr 27, 2006 7:55 pm Post subject: Cutting mouse pituitary at 9 months (not later) ups lifespan |
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Interesting findings from R. Wilson Powers III and the team at the Jackson Laboratory. They seem to find that removing the pituitary specifically a 9 months, or approximately 23-28% through the lifespan, extends lifespan maximally. It influences both average and maximum lifespan.
The mice subjected to this treatment ate less, so it may be another way of imposing caloric restriction. They lived longer than controls, so whatever happened in this experiment, we are talking about "something" related to "aging". In the supplemental data, they apparently state that adding thyroxine or corticosterone did not modify this effect, suggesting that these hormones are not mediating any substantive effect in this specific experimental context.
All in all, very interesting. If I had to venture a guess..., well, I will withhold my theorizing on this one....maybe I should write a paper concerning what I think it going on! I guess you could go in a lot of different directions on this one!
But, regardless of what is causing it, endocrinology is very powerful!
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| "Hypophysectomy at 1 month of age extended life span significantly (15%), but hypophysectomy at 9 months of age extended life span to the greatest magnitude (21%) of any age we tested. These results demonstrate pituitary hormone withdrawal can extend life span even if these hormones are removed relatively late in life." - Mechanisms of Ageing and Development |
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