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There is an interesting new paper in an American Chemical Society journal from someone that claims that water can be dropped in temperature much lower than previously appreciated without ice formation.

This is important for those that study the beneficial possibilities seen with cooling body tissues. Of course, everyone has heard of the "cryonics" movement, where the goal is to freeze tissues so that they can be "restored" in some manner later on. Some of the biggest reservations that the scientific community has had towards this possibility are the facts that water, the "solvent of life", freezes when it gets very cold, and ice has less density than water. Because of this, ice crystals will begin to "shear" all of the organelles within the cell, in effect producing massive cytologic damage and largely cancelling out the benefits one can generate through temperature reduction.

In any case, it is an interesting finding, and is one step, among many, that could lead to interesting new advances in this field that I had long ago "written off" because of this physicochemical constraint.

In more immediate terms, the benefits of "cooling the brain" in all manner of neurologic emergencies keeps being shown time and time again, and so I am more receptive to this line of reasoning than I had been. Body temperature can be your worst enemy in the appropriate physiologic context.

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