cron-web.org

[A1CR]

It appears that a new paper that compares the time course of
physiological
changes occurring with low-carbohydrate versus a low-fat,
CRed diet finds
that the initial positive results of the low-carbohydrate
diets are largely
not retained over time. That obese individuals were
examined may reduce the
significance of the findings. The paper below is not
-.

Cardillo S, Seshadri P, Iqbal N.
The effects of a low-carbohydrate versus low-fat diet on
adipocytokines in
severely obese adults: three-year follow-up of a randomized
trial.
Eur Rev Med Pharmacol Sci. 2006 May-Jun;10(3):99-106.
PMID: 16875041
http://en.wikipedia.org/wiki/Adipocytokine are
associated with insulin
resistance and cardiovascular disease and can be modified
with weight loss.
... we previously demonstrated weight loss and a reduction
in leptin in
obese adults who followed a low-carbohydrate diet for 6
months ... 132 obese
adults with a body mass index of > or = 35 kg/m2 were
randomized to receive
one year of dietary counseling to follow either a
low-carbohydrate diet < 30
g/day (LC) or a caloric-restricted diet (reduced by 500
calories/day with <
30% of calories from fat) (LF). Weight, leptin, adiponectin,
TNF-alpha, CRP,
and insulin were measured at 0, 6, and 36 months (24 months
post-counseling). Follow-up data at was collected for 53
participants who
returned at 36 months. RESULTS: Mean weight change from
baseline was not
different between the groups at 36 months. Between 6 and 36
months weight
was unchanged for LF, while LC appeared to regain weight [+
4.84 +/- 35.6 kg
(+ 3.0%)]. This difference, however, was not significant (p
= 0.08). Leptin
was unchanged in LF at both 6 and 36 months. In LC leptin
decreased by 8.49
+/- 6.4 ng/mL or 22.7% at 6 months (p < 0.001) and increased
by 10.68 +/-
25.2 ng/mL or 41.9% between 6 and 36 months (p = 0.02).
There were no
differences in insulin, adiponectin, TNF-alpha, or CRP
between the groups.
CONCLUSIONS: Favorable changes in leptin that accompany
weight loss are not
sustained in individuals who followed a low-carbohydrate
diet for one year.
A low-carbohydrate diet had no significant effect on
insulin, adiponectin,
TNF-alpha, or CRP compared to a low-fat diet at 36 months.