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[A1CR]

Although the below not - paper presented results
consistent with
those such as Drs. Spindler et al, the interpretation of the
effects that
this paper reports and their interpretation may be of note
regarding how
rapidly and efficiently the effects of CR are manifest. In
this manner, the
CRed (or CRONed) body may become more energy efficient.

Selman C, Kerrison ND, Cooray A, Piper MD, Lingard SJ,
Barton RH, Schuster
EF, Blanc E, Gems D, Nicholson JK, Thornton JM, Partridge L,
Withers DJ.
Coordinated multi-tissue transcriptional and plasma
metabonomic profiles
following acute caloric restriction in mice.
Physiol Genomics. 2006 Aug 1; [Epub ahead of print]
PMID: 16882887 http://tinyurl.com/z8uot
... Caloric restriction (CR) ... Recent studies
demonstrate that acute
CR alters mortality rates within days in flies. Multi-tissue
transcriptional
changes and concomitant metabolic responses to acute CR have
not been
described. ... subjected to acute CR. Liver and muscle
showed increased gene
expression associated with fatty acid metabolism and a
reduction in those
involved in hepatic lipid biosynthesis. Glucogenic amino
acids increased in
plasma and gene expression for hepatic gluconeogenesis was
enhanced.
Increased expression of genes for hormone-mediated signaling
and decreased
expression of genes involved in protein binding and
development occurred in
hypothalamus. Cell proliferation genes were decreased and
cellular transport
increased in colon. Acute CR captured many, but not all,
hepatic
transcriptional changes of long-term CR. Our findings
demonstrate a clear
transcriptional response across multiple tissues during
acute CR, with
congruent plasma metabolite changes. Liver and muscle
switched gene
expression away from energetically expensive biosynthetic
processes towards
energy conservation and utilization processes, including
fatty acid
metabolism and gluconeogenesis. Both muscle and colon
switched gene
expression away from cellular proliferation. Mice undergoing
acute CR
rapidly adopt many transcriptional and metabolic changes of
long-term CR,
suggesting that the beneficial effects of CR may require
only a short-term
reduction in caloric intake.