cron-web.org

[A1CR]

"Is the CCK2 [a gastrointestinal satiety signal] receptor
essential for
normal regulation of body weight and adiposity?

Chen H, Kent S, Morris MJ.

Is the CCK2 receptor essential for normal regulation of body
weight and
adiposity?

Eur J Neurosci. 2006 Sep 8; [Epub ahead of print]
PMID: 16965546

Cholecystokinin (CCK) is a gastrointestinal satiety
signal released
from the duodenum to terminate feeding, via CCK1 receptors.
CCK2 receptors
are considered to be involved in anxiety. CCK2 receptor
knockout mice have
increased body weight and food intake. ... neuropeptide Y
(NPY), a powerful
stimulator of feeding. Adult (10 week) CCK2 receptor
knockout and wild-type
mice ... Female CCK2 receptor knockout mice weighed more
than control mice
(22.0 +/- 0.2 vs. 19.9 +/- 0.4 g, P < 0.05), with this
difference being less
marked in male mice (26.4 +/- 0.4 vs. 25.6 +/- 0.6 g). Fat
masses in all
locations sampled were significantly smaller in CCK2
receptor knockout mice
of both genders (P < 0.05), resulting in lower plasma leptin
and insulin
levels. NPY concentrations were significantly increased in
arcuate nucleus
and anterior hypothalamus in both male and female CCK2
receptor knockout
mice, and total hypothalamic NPY content was increased by 7
and 9% in males
and females, respectively (P < 0.05). CCK2 receptor deletion
was associated
with increased body weight and hypothalamic NPY content, but
reduced fat
masses and plasma leptin and insulin. ...