cron-web.org

[A1CR]

Hormesis has been proposed to be a fundamental pillar for
the mechanism of
CR.

1. Masoro EJ.
The role of hormesis in life extension by dietary restriction.
Interdiscip Top Gerontol. 2007;35:1-17.
PMID: 17063030

The level of food restriction that results in life extension
and retarded
aging in rodents also enhances their ability to cope with
intense stressors.
Moreover, this level of dietary restriction (DR) leads to a
modest increase
in the daily peak concentration of plasma free
corticosterone, which
strongly points to DR as a low-intensity stressor. These
findings suggest
that hormesis plays a role in the life-extending and
anti-aging actions of
DR. The evidence for and against this possibility is
considered, and it is
concluded that hormesis does have an important role

2. Masoro EJ.
Dietary restriction-induced life extension: a broadly based
biological
phenomenon.
Biogerontology. 2006 May 27; [Epub ahead of print]
PMID: 16732403

It is concluded that dietary restriction will extend the
life of all species
in the Animalia Kingdom, including the human species. This
conclusion is
based on the fact that hormesis is a component of the
life-extending action
and the other anti-aging effects of dietary restriction. It
is also
concluded that given the currently available database, it is
not possible to
predict the quantitative effect of dietary restriction on
the human life
span.