cron-web.org

[A1CR]

In the http://en.wikipedia.org/wiki/Caenorhabditis_elegans
worm, "Increased
dosage of a sir-2 gene extends lifespan in Caenorhabditis
elegans", was said
in the http://tinyurl.com/ykl3u5 paper and the
http://tinyurl.com/yekb9p paper says that CR may affect
longevity via various means.

Kaeberlein TL, Smith ED, Tsuchiya M, Welton KL, Thomas JH,
Fields S, Kennedy
BK, Kaeberlein M.
Lifespan extension in Caenorhabditis elegans by complete
removal of food.
Aging Cell. 2006 Nov 1; [Epub ahead of print]
PMID: 17081160

A partial reduction in food intake has been found to
increase lifespan in
many different organisms. We report here a new dietary
restriction regimen
in the nematode Caenorhabditis elegans, based on the
standard agar plate
lifespan assay, in which adult worms are maintained in the
absence of a
bacterial food source. These findings represent the first
report in any
organism of lifespan extension in response to prolonged
starvation. Removal
of bacterial food increases lifespan to a greater extent
than partial
reduction of food through a mechanism that is distinct from
insulin/IGF-like
signaling and the Sir2-family deacetylase, SIR-2.1. Removal
of bacterial
food also increases lifespan when initiated in
postreproductive adults,
suggesting that dietary restriction started during middle
age can result in
a substantial longevity benefit that is independent of
reproduction.