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[A1CR]

It appears from the paper below that maybe CRed animals make
more of the healthy long-chain fatty acids?

Lehnert SA, Byrne KA, Reverter A, Nattrass GS, Greenwood PL,
Wang YH, Hudson
NJ, Harper GS.
Gene expression profiling of bovine skeletal muscle in
response to and
during recovery from chronic and severe undernutrition.
J Anim Sci. 2006 Dec;84(12):3239-3250.
PMID: 17093216

Gene expression profiles of LM from beef cattle that
underwent significant
postweaning undernutrition were studied using complementary
DNA (cDNA)
microarrays. After 114 d of undernutrition, the RNA from LM
showed 2- to
6-fold less expression of many genes from the classes of
muscle structural
proteins, muscle metabolic enzymes, and extracellular matrix
compared with
animals on a rapid growth diet. The expression levels of
these genes had
mostly returned to pretreatment levels after 84 d of
realimentation. The
gene expression changes associated with undernutrition and
BW loss showed an
emphasis on downregulation of gene expression specific to
fast-twitch
fibers, typical of starving mammals, with a preferential
atrophy of
glycolytic fast-twitch fibers. We also identified a small
group of genes
that showed 2- to 5-fold elevated expression in LM after 114
d of
undernutrition. Putative roles for these genes in atrophying
skeletal muscle
are regulation of myogenic differentiation (CSRP3),
maintenance of
mesenchymal stem cells (CYR61), modulation of membrane
function (TM4SF2),
prevention of oxidative damage (SESN1), and regulation of
muscle protein
degradation (SQSTM1). A significant increase in stearoyl-CoA
desaturase
(SCD) gene expression was observed in atrophying muscle,
suggesting either
that increased fatty acid synthesis is part of the tissue
response to
caloric restriction, or that SCD plays another role in
energy metabolism in
the mixed cellular environment of bovine skeletal muscle.