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mTOR activated in obesity; Marette's findings

 
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CRON4healthyfuture
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PostPosted: Thu Feb 09, 2006 2:49 am    Post subject: mTOR activated in obesity; Marette's findings Reply with quote
http://endo.endojournals.org/cgi/content/abstract/146/3/1473

This is another important finding that shows how being obese can activate the mTOR protein robustly. There is some reason to believe that this could promote disease and possibly aging.

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"Time-course studies also revealed that mTOR and S6K1 activation by insulin was accelerated in tissues of obese rats, in association with increased inhibitory phosphorylation of insulin receptor substrate-1 (IRS-1) on Ser636/Ser639 and impaired Akt activation. The relationship between mTOR/S6K1 overactivation and impaired insulin signaling to Akt was also examined in hepatic cells in vitro. Insulin caused a time-dependent activation of mTOR and S6K1 in HepG2 cells." - Endocrinology

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