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Proinsulin, a marker for insulin, suppresses IGFBP-1

 
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CRON4healthyfuture
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PostPosted: Thu Feb 09, 2006 2:59 am    Post subject: Proinsulin, a marker for insulin, suppresses IGFBP-1 Reply with quote
This is a good example of how endocrinological considerations "play out" in a real, living human being. A diabetic kid will have low IGFBP-1 because runaway insulin signaling is suppressing it.

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Quote:
"Conclusion: These findings suggest that fasting serum PI levels may be a better predictor than fasting insulin levels for the future development of type 2 DM and cardiovascular disease in obese children, and PI, in addition to insulin, contributes to the suppression of hepatic IGFBP-1 production."
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