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It appears that, "data indicate a decrease in lipid
peroxidation,
improvement in the antioxidant defense systems and
restoration of the redox
status in the liver by caloric restriction." Th


Ugochukwu NH, Figgers CL.
Dietary caloric restriction improves the redox status at the
onset of
diabetes in hepatocytes of streptozotocin-induced diabetic rats.
Chem Biol Interact. 2006 Oct 27; [Epub ahead of print]
PMID: 17123496

Enhanced production of free radicals and oxidative stress
induced by
hyperglycemia play a central role in the pathogenesis of
diabetes and its
complications. This study assessed the attenuation by
dietary caloric
restriction on the oxidative and lipid peroxidative effects
of diabetes in
the liver through reduction in body and organ weights and
concomitant
metabolic changes. Three-month-old male Wistar rats were
subjected to ad
libitum feeding and 30% caloric restriction for 9 weeks
before induction of
diabetes by intraperitoneal injection of 35mg/kg body weight
streptozotocin.
The animals were sacrificed 2 weeks after streptozotocin
treatment depicting
the onset of diabetes. Caloric restriction significantly
reduced the organ
weights (p<0.01), malondialdehyde (p<0.01) and catalase
activity (p<0.01),
but significantly increased glutathione reductase activity
(p<0.01), and
GSH/GSSG ratios (p<0.05). Caloric restriction also
non-significantly reduced
reactive oxygen species, superoxide dismutase and oxidized
glutathione but
increased glutathione peroxidase activity and reduced
glutathione levels in
the diabetic rats. Our data indicate a decrease in lipid
peroxidation,
improvement in the antioxidant defense systems and
restoration of the redox
status in the liver by caloric restriction. Therefore, this
could provide a
non-invasive antioxidant therapy early in diabetes to
prevent the
development of the complications associated with the disease.