cron-web.org

[A1CR]

It seemed that there may be pluses and minuses of eating two
types of simple
sugars, honey or http://en.wikipedia.org/wiki/Dextrose when
CRing. Having
lower white blood cells seems to be a CR phenotype that is
often seen.
Another control, in which CRed animals eating a diet without
added sugars,
may have further informed.

Al-Waili NS, Saloom KY, Al-Waili TN, Al-Waili AN, Akmal M,
Al-Waili FS,
Al-Waili HN.
Influence of various diet regimens on deterioration of
hepatic function and
hematological parameters following carbon tetrachloride: a
potential
protective role of natural honey.
Nat Prod Res. 2006 Nov;20(13):1258-64.
PMID: 17127519

The objective was to assess the effects of commercial
regular diet as
control, total food restriction with honey, commercial
regular diet with
dextrose, or total food restriction with dextrose, on blood
variables after
carbon tetrachloride (CCl4) administration. Sprague Dawley
albino rats were
divided into four groups, 10 rats each; Group 1 rats were on
commercial
regular diet, Group 2 rats were on commercial regular diet
with 50%
dextrose, Group 3 rats were on total food restriction with
50% dextrose, and
Group 4 rats were on total food restriction with 50% honey.
Rats in all the
groups were i.m. administered CCL4 (2.4 mL kg b. wt.-1).
Blood tests
including ALT, AST, serum albumin, serum protein, BUN, blood
glucose (BG),
hemoglobin (Hb), and white blood cell (WBC) were performed
before CCl4
administration and repeated after 48 and 96 h of
post-injection. In Group 1,
CCl4 caused significant elevation in AST and ALT, and
decrease in BS, WBC,
and BUN; lower elevation in AST and ALT at 48 h and
decreased AST and ALT at
96 h were obtained when dextrose was added to commercial
regular diet (Group
2). Using dextrose alone (Group 3), though there was
significant elevation
of AST and ALT and decrease in BUN and WBC as compared to
baseline values,
significant decrease in ALT, AST, and BUN as compared to
control was
obtained. During absolute honey feeding (Group 4), elevation
in AST and ALT
obtained, following CCl4 administration was significantly
less than the
values obtained in all other groups; with lower elevation in
AST and ALT as
compared to baseline values. Honey increased serum albumin,
serum protein,
BG, and caused lower reduction in Hb. Conclusively,
exclusive honey feeding
(50% concentration) significantly modifies and ameliorates
biochemical and
hematological changes obtained after CCl4 injection.