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What is "Signal Transduction"?

 
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A1CR
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PostPosted: Thu Feb 09, 2006 9:21 am    Post subject: What is "Signal Transduction"? Reply with quote

Some of you may be wondering what "Signal Transduction" is and why it's important. Here's the definition from Wikipedia:

Quote:
In biology, signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. Such processes take place in as little time as a millisecond or as long as a few seconds. Slower processes are rarely referred to as signal transduction.

In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. In such cases the chain of steps is referred to as a "signaling cascade" or a "second messenger pathway" and often results in a small stimulus eliciting a large response.

In bacteria and other one-cell organisms, the variety of signal transduction processes of which the cell is capable influences how many ways it can react and respond to its environment. In a less direct way the same is true of animals and plants. Sensing in all forms of life depends, at the cellular level, on signal transduction.


read more of Wikipedia's definition here: http://en.wikipedia.org/wiki/Signal_transduction

Other reference links:

http://www.biochemweb.org/signaling.shtml

http://cscs.umich.edu/~crshalizi/notebooks/signal-transduction.html
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A1CR
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Joined: 18 Jan 2006
Posts: 559

PostPosted: Thu Feb 09, 2006 10:40 am    Post subject: Cell Signaling and Communications Reply with quote

Dug out a first-year university biology textbook, and read the end-of-chapter summary of Cell Signaling and Communications. Here's the gist:

Signals

    Cells receive many signals from both the physical environment and other cells.

    Signaling involves three steps: the binding of a signal by a receptor, the transduction of the signal within the cell, and the ultimate cellular response.


Receptors

    Cells respond to signals only if they have specific receptor
    proteins that can bind to those signals.

    Depending on the nature of the signal, the receptor may be at the plasma membrane or in the cytoplasm of the target cell.

    Membrane receptors include ion channels, protein kinases. and G protein-linked receptors.


Transducers

    The events of signal transduction may be direct, occurring at the plasma membrane, or indirect, involving the formation of a second messenger.

    Protein kinase cascades amplify a response to receptor binding.

    Second messengers include cyclic AMP, the lipid-derived substances phosphatidylinositol and diacylglycerol, calcium ions, and the gas nitric oxide.


Effects

    The ultimate cell response to a signal may be the opening of membrane channels, the alteration of enzyme activities, or changes in gene transcription.



Direct Intercellular Communication

    Animal cells can communicate directly, through small pores in their plasma membranes called gap junctions. Small molecules and ions can pass through these channels.

    Plant cells are connected by somewhat larger pores called plasmodesmata, which traverse both membranes and cell walls.
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