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[CRON4healthyfuture]

This is a very interesting new study in the journal Circulation that echoes a sentiment that is increasing about many physicians that are studying the problems of hypertension and cardiovascular disease. Basically, what everyone is realizing is that by the time the patient walks into a clinic presenting with advanced cardiovascular disease, it is to some extent "too late" to intervene in a manner that completely eliminates that patient's risk of major sudden deterioration in their health status to a cardiovascular event.

Because of this realization, more and more physicians are becoming proactive about recommending aggressive interventions at earlier points in the lifespan to prevent problems. In this study, it was determined that the absence of risk factors at age 50 seemed to indicate that the lifetime risks of cardiovascular risk factors was minimized.

This has important "practical" implications for caloric restriction as well. Some of the best literature we have about human health pertains to the experience of cardiovascular disease in the Western world. Someone who is under a CR/CRON regimen may face unique health challenges that do not mirror this experience exactly, so some interventions that maximize cardiovascular health may not be as efficacious or beneficial when superimposed upon a CR/CRON regimen. However, until the appropriate experimentation is conducted, the exact magnitude of various interventions as well as the precise effects of mixing interventions remains undetermined.

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http://circ.ahajournals.org/cgi/content/abstract/CIRCULATIONAHA.105.548206v1

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"Conclusions--The absence of established risk factors at 50 years of age is associated with very low lifetime risk for CVD and markedly longer survival. These results should promote efforts aimed at preventing development of risk factors in young individuals. Given the high lifetime risks and lower survival in those with intermediate or high risk factor burden at 50 years of age, these data may be useful in communicating risks and supporting intensive preventive therapy."

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