|
cron-web.org
Calorie Restriction with Optimum Nutrition Forum
|
|
|
| Author |
Message |
A1CR
Site Admin
Joined: 18 Jan 2006
Posts: 559
|
 Posted: Thu Feb 16, 2006 7:07 pm Post subject: Exercise, CRON, & systemic oxidative stress |
 |
|
Exercise, caloric restriction, and systemic oxidative stress
It seems that intense exercise "siginificantly" reduces oxidation regardless of CR, but more studies are needed.
| Quote: |
... reactive oxygen species (ROS), the molecules causing oxidative stress,
are mitochondrial superoxide ions and neutrophil-derived oxidative radicals.
Circulating antioxidants contribute to the protection against oxidative
stress. Although the formation of ROS and secretion of antioxidants are
independently regulated by exercise and diet, little is known about their
combined effect. We hypothesized that relatively brief, intense exercise
training may reduce systemic oxidation via an intrinsic mechanism,
independent of changes in circulating antioxidants and of neutrophil-derived
enzymes (as may be caused by concomitant caloric restriction). Methods:
Nineteen volunteers exercised for 7 days, 3 hours/day at 75% of oxygen
uptake. Caloric intake was either 110% of caloric expenditure (high calorie,
n = 10) or 75% of caloric expenditure (low calorie, n = 9). ...
myeloperoxidase (MPO), interleukin-x (IL-x), white blood cells (WBCs) ...
Results: Serum F2-isoprostanes (microg/mL), markers of lipid peroxidation,
were similarly reduced after 7 days of exercise in the high-calorie (from 35
+/- 4 to 27 +/- 2) and low-calorie (from 35 +/- 3 to 24 +/- 2) groups.
Similar reductions were observed in IL-x concentrations. Conversely, no
change was observed in circulating concentrations of the antioxidant
catalase. Whereas total WBCs and neutrophil counts were significantly
reduced in the low-calorie group only, no difference in neutrophil-derived
MPO was measured between groups. Conclusion: A significant reduction in
systemic oxidation may occur relatively early during intense exercise
training in healthy young men, independent of caloric intake. The potential
contribution to these effects of circulating antioxidants and
neutrophil-derived oxidative enzymes will require further investigation. |
Galassetti PR, Nemet D, Pescatello A, Rose-Gottron C, Larson J, Cooper DM.
Exercise, caloric restriction, and systemic oxidative stress.
J Investig Med. 2006 Mar;54(2):67-75.
PMID: 16472476 |
|
| Back to top |
|
 |
|
|
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum
|
|
Powered by phpBB © 2001, 2005 phpBB Group
|
Search
Log in
