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Calorie Restriction with Optimum Nutrition Forum
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CRON4healthyfuture
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 Posted: Fri Feb 17, 2006 3:50 am Post subject: Signal Transduction of 80% calorie reduction |
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This study ememplifies how signal transduction networks are affected by extreme food reduction. A less extreme shift would probably be manifested by less extreme caloric restriction.
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| "Body weight was reduced 30% with ND while CTL gained 17%. Diaphragm mass decreased by 29% with ND. Muscle IGF-I mRNA abundance was reduced by 63% in ND animals. PI3 kinase/Akt/mTOR pathway: ND resulted in a 55% reduction in phosphorylated (Ser473) Akt. The phosphorylation of mTOR at Ser2448 was reduced by 85% with ND. Downstream effectors important in translation initiation were also impacted by ND. Phosphorylated (Thr389) p70S6K was significantly reduced (35%) with ND. The translational repressor 4E-BP1 was also significantly dephosphorylated with ND. PI3 kinase/Akt/Glycogen Synthase Kinase (GSK)-3 pathway: The phosphorylation (Ser21/9) of both GSK-3/ was increased (55/45%) with ND. MAP kinase/ERK pathway: The phosphorylation (Thr202/Tyr204) of both ERK1/2 (p44/p42) was reduced (64/55%) with ND. The concentrations of total protein for all signaling intermediates of the 3 pathways were preserved. We conclude that short-term ND altered the phosphorylation states of key proteins of several pathways involved in protein turnover. This forms the framework for future studies aimed at identifying therapeutic targets in the management of short-term nutritionally induced cachectic states." - J Appl Physiol (February 16, 2006). |
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