|
|
| Author |
Message |
A1CR
Site Admin
Joined: 18 Jan 2006
Posts: 559
|
 Posted: Thu Feb 23, 2006 4:34 am Post subject: CRON Reduces DNA Damage in Elderly People |
 |
|
Here is an important study that found "undernutrition without malnutrition" reduces markers of DNA damage in an elderly human population. It's never too late to CRON!
| Quote: |
Caloric restriction (CR), undernutrition without malnutrition, is a successful
method of extending the life span and reducing the incidence of several diseases. In
animals, CR can reach 40% with beneficial effects, whereas in human beings, CR must
be moderate (only 10%-20%) to avoid health risks. We have examined whether
undernutrition without malnutrition is a protective factor for DNA damage in the
elderly. The sample included a total of 260 older subjects: 96 well-nourished
subjects, 52 subjects with undernutrition without malnutrition (CR 10%-20%), and 112
overweight subjects, all diagnosed as clinically healthy. DNA damage in peripheral
blood lymphocytes was assessed through an alkaline unicellular electrophoresis
procedure (comet assay). Fifty-six percent of the well-nourished subjects, 38% of
the CR, and 44% of the overweight had DNA damage. Odds ratio (OR) of logistic
regression analysis for DNA damage were: gender (men; OR 2.1, 95% CI [confidence
interval] 1.19-3.71, P < .01), age (≥70 years; OR 1.7, 95% CI 1.05-3.02, P =
.03), overweight (body mass index ≥27; OR 0.67, 95% CI 0.38-1.19, P = .18) and
CR subjects (OR 0.40, 95% CI 0.19-0.82, P < .01). The groups of CR women and 60- to
69-year olds had a lower percentage of DNA damage than CR men and 70-year olds,
respectively (P < .01 and P < .001). Present results suggest that a 10% to 20% CR is
a protective factor for DNA damage in elderly people and that CR has better effects
on women and on subjects aged 60 and 69 years. |
Undernutrition without malnutrition as a protective factor to prevent DNA damage
in the elderly
Nutrition Research, Volume 25, Issue 3, March 2005, Pages 271-280
Víctor M. Mendoza-Núñez, Martha A. Sánchez-Rodríguez, Raquel Retana-Ugalde, Luis A.
Vargas-Guadarrama and Mario A. Altamirano-Lozano |
|
| Back to top |
|
 |
|
|
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum
|
|
|
Search
Log in
