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A1CR
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Joined: 18 Jan 2006
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 Posted: Wed Jan 18, 2006 5:19 am Post subject: Gene-expression profile of the ageing brain in mice |
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Heavyweight CR researchers from the Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin, USA, explore "Gene-expression profile of the ageing brain in mice."
Lee CK, Weindruch R, Prolla TA.
Gene-expression profile of the ageing brain in mice.
Nat Genet. 2000 Jul;25(3):294-7.
PMID: 10888876
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| Ageing of the brain leads to impairments in cognitive and motor skills, and is the major risk factor for several common neurological disorders such as Alzheimer disease (AD) and Parkinson disease (PD). Recent studies suggest that normal brain ageing is associated with subtle morphological and functional alterations in specific neuronal circuits, as opposed to large-scale neuronal loss. In fact, ageing of the central nervous system in diverse mammalian species shares many features, such as atrophy of pyramidal neurons, synaptic atrophy, decrease of striatal dopamine receptors, accumulation of fluorescent pigments, cytoskeletal abnormalities, and reactive astrocytes and microglia. To provide the first global analysis of brain ageing at the molecular level, we used oligonucleotide arrays representing 6,347 genes to determine the gene-expression profile of the ageing neocortex and cerebellum in mice. Ageing resulted in a gene-expression profile indicative of an inflammatory response, oxidative stress and reduced neurotrophic support in both brain regions. At the transcriptional level, brain ageing in mice displays parallels with human neurodegenerative disorders. Caloric restriction, which retards the ageing process in mammals, selectively attenuated the age-associated induction of genes encoding inflammatory and stress responses. |
Synopsis:
Which genes are affected positively and negatively in aging, and how does calorie restrction affect these patterns. Calorie restriction seems to maintain youthful brain gene expression profiles.
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