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Calorie Restriction with Optimum Nutrition Forum
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CRON4healthyfuture
Guest
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 Posted: Tue Feb 28, 2006 5:32 am Post subject: Testosterone synthesis blows out testis |
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I think older guys often wax nostalgic for those old testosterone-fueled days.
Turns out that those days specifically fried their testes. 
Can't win 'em all.
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http://www.pnas.org/cgi/content/abstract/0505827103v1
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| "The depletion of germ cells found in wild-type animals was associated with a higher content of peroxynitrites, a marker of reactive oxygen species, and a higher number of apoptotic cells compared with PACAP-/- mice. Our results show that testicular aging is delayed in PACAP-/- animals. Because the expression levels of steroidogenic factors are low and constant over time in knockout animals, a proposed mechanism for the protection against testicular degeneration is that production of reactive oxygen species, a byproduct of steroidogenesis that induces apoptosis, is down-regulated in PACAP-/- animals." - Proceedings of the National Academy of Sciences |
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