cron-web.org

[A1CR]

[posted on behalf of CRON4healthyfuture]

There are some things I like about the Barja research, and some things I don't like. But one thing is for certain, this dude throws the gauntlet on the table.

MLSP is maximum lifepan potential. This is an interesting metric to fixate on, and something I would encourage more researchers to consider in their analyses. I guess lifespan research is so difficult to begin with, that to start requiring the specific enhancement of maximum lifespan may be an additional imposition that the research community will be loathe to consider.

In any case, Barja and Reinald Pamplona go ahead and say HALF OF CR is METHIONINE RESTRICTION.

Here is another little factoid they advance: 80% METHIONINE RESTRICTION GRANTS A 44% MLSP INCREASE.

40% CALORIC RESTRICTION GRANTS A 40% MLSP INCREASE.

44% versus 40%.......Well, statistically, it's a wash, but in absolute terms, methionine restriction is "better", from Barja and Pamploma's perspective.

But, above all of that minutae, there is a very important concept being advanced here. Strict thermodynamics has very little to do with what is "really" going on, whatever it is.

PR is Protein Restriction, the benefits of which they end up arguing is "mediated" almost entirely by methionine restriction.

=-=-=-=-=-=-=-=-=-=-=

"Therefore, the decrease in methionine intake could be responsible for all or most of the increase in MLSP observed in PR as well as for around 50% of the increase in MLSP observed in CR. "

=-=-=-=-=-=-=-=-=-=-=-=

http://dx.doi.org/10.1016/j.bbabio.2006.01.009