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cron-web.org Calorie Restriction with Optimum Nutrition Forum
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A1CR Site Admin
Joined: 18 Jan 2006 Posts: 559
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Posted: Wed Mar 15, 2006 5:13 am Post subject: Skin cell telomeres lose 9 to 11 base pairs per year of your |
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[posted on behalf of CRON4healthyfuture]
Skin cell telomeres lose 9 to 11 base pairs per year of your life
Human subjects....
Interestingly, sun-exposure did not impact this phenomenon.
I don't really consider the changes associated with sun-exposure as "true" aging, as they are really just runaway fibrosis and perturbation of the extracellular matrix, in my opinion.
So, I think that "photoaging" is not "aging". You still end up looking like a bloodhound, though.
Additionally, sun exposure fries your differentiated cells more than your stem cells.
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16524700
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"Telomere length in the epidermis and in the dermis was reduced with age, and average telomere shortening rates in the epidermis and in the dermis were 9 and 11bp/yr, respectively. Unexpectedly, telomere length was not significantly different between epidermis from sun-exposed sites and from sun-protected sites. CONCLUSION: We could not show the evidence that telomere shortening is associated with photoaging of the skin." - PMID: 16524700 |
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