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This was a recent correspondence in the journal Mechanisms of Ageing. It indicates that, in contrast to what is seen in yeast, nicotinamide, known as Vitamin B3, extends replicative lifespan. This is a measure of how many times a cell can divide before "having to stop".

They articulate that the specific manner by which nicotinamide contributes to extended replicative lifespan in primary human cells is through a hSIRT1-independent mechanism. They do acknowlege, however, that the entirety of hSIRT1's effects are not known. This is important because you cannot really look for what you don't know about.

In any case, they also emphasize that there is an "age-dependence" to this effect. Younger cells benefit more from nicotinamide supplementation than older cells in terms of replicative lifespan. They cite previous research by Matuoka et. al that indicates that older cells may still indeed benefit from nicotinamide by means of a phenotype reversal to "youth". However, this present study did not find that nicotinamide supplementation could enhance replicative lifespan in older cells.

So what does this mean? Good question. I am not entirely even certain it is "universally good" to have primary cells that can divide more. Cancers love to divide! Ask a cytopathologist what do "mitotic figures" indicate, and you will get a rather unquivocal reply.

However, cellular senescence has recently been demonstrated in baboon tissue, with telomeric dysfunction demonstrable in an ever-increasing proportion of the cells of one's tissues as one ages, so early nicotinamide supplementation could : THEORETICALLY forestall this molecularly ignomious conclusion to the concert of life........

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