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This is an interesting study. They overexpressed a gene in mice, and they lived longer. The gene is metallothionein, and it did a lot of things that helped the mice at the cellular level. There was reduced "oxidative stress" and improved enzyme activities. There was also improved calcium-handling. Additionally, they assessed cardiac function and found suppression of age-related dysfunction.

Intriguingly, there was a marked suppresion in the age-related increase in RhoA density. They showed how important this can be when they administered a Rho kinase inhibitor and suppressed much of the dysfunction that was seen in the aged cardiac cells.

It will be interesting to see if this can be replicated, and what the implications are for many perspectives on aging. These findings are reminiscent of the recent catalase overexpression study that also prolongs life. There may be many enzymes and proteins that mediate lifespan.

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