Posted: Thu Apr 27, 2006 12:50 am Post subject: Leucine in diet activates Leptin and mTOR
There are interesting findings, although there are so many possible implications it is challenging to know how to react to this particular discovery.
In any case, these researchers found that leucine in the diet is one of the more potent signals for leptin. They correlated the ingestion of meals, some of which were esigned to emphasize leucine, with elevations in intracellular mTOR activity, as well.
The significance of this for aging research is that TOR mutations have extended lifespan in lower organisms. It may be that dietary leucine is something that may hurt you in the long run.
"In the first study we correlated changes in plasma insulin and Leu, to mTOR signaling pathway activation and plasma leptin at different times during meal feeding.......Stimulation of leptin secretion was reduced approximately 40% in animals provided the Leu deficient meal. Further reductions where not observed by removing the other amino acids. Thus Leu appears to regulate most of the effects of dietary amino acids upon the postprandial rise in plasma leptin, but is only responsible for part of the leptin response to meal feeding." - Am J Physiol Endocrinol Metab (April 25, 2006).
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