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Bisphosphonates are medications that "strengthen" bones by reducing bone "turnover". However, in the process, they disrupt bone "remodeling". Bones are constantly sustaining trauma everytime you move around, and so when they sustain "microfractures", the bone cells (osteoblasts) will mobilize and "fix the breaks". If bisphosphonates are "in their way", they won't be able to keep up with sustained damage, and so you can see the problem that you see here, which is "death of the jaw bone" after major dental procedures.

Another interesting thing here is that people on caloric restriction tend to show lowered bone mineral density (BMD), and so many attempt to address that problem biomedically with bisphosphonates.

Most clinical personnel are trained in an almost Pavlovian sense to treat any deviation in BMD from the statistical norms aggressively. I worry, though, that what is good for the "general public" may not be the best course of action for someone undertaking a caloric restriction regimen, but only time, with the additional evidence that it entails, will answer these lingering questions. Additionally, it may turn out that the benefits outweigh the risks.

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