cron-web.org

[A1CR]

How are those who are addicted to drugs affected by CR, as a
previous
message http://tinyurl.com/rkhen appears to have examined?
The paper below,
appears to find that "as demonstrated for
footshock-induced reinstatement of drug-seeking, brain
http://en.wikipedia.org/wiki/Corticotropin-releasing_factor
, but not
http://en.wikipedia.org/wiki/Corticosterone , plays a
critical role in acute
food-deprivation-induced reinstatement of heroin seeking."
Such conclusions
may be consistent with the report in the previous message
http://tinyurl.com/p3ppn that "Food is also a very powerful
reinforcer, and
in some circumstances may be more reinforcing than drugs of
abuse. For
example, heroin dependent baboons reduced their responding
for heroin when
they had to choose between heroin and food and opportunities
to obtain
heroin or food were decreased, while responding for food was
maintained."

Shalev U, Finnie PS, Quinn T, Tobin S, Wahi P.
A role for CRF, but not corticosterone, in acute
food-deprivation-induced
reinstatement of heroin seeking in rats.
Psychopharmacology (Berl). 2006 Aug;187(3):376-84. Epub 2006
Jun 1.
PMID: 16850287 http://tinyurl.com/l3paa
RATIONALE: Acute 1-day food deprivation reinstates
heroin seeking in
rats via a leptin-dependent mechanism. However, leptin has
no effect on
footshock- or heroin-priming-induced reinstatement of drug
seeking. These
data may indicate that the neuronal systems underlying
food-deprivation-induced reinstatement are dissociable from
those involved
in reinstatement induced by footshock stress. ... brain
corticotropin-releasing factor (CRF) .... Experiment 1:
After heroin
self-administration training, the rats were divided into two
groups, which
received either bilateral adrenalectomy surgery or sham
surgery. Next, the
rats were given 7-10 days of extinction training (during
which lever presses
were not reinforced with heroin). The rats were subsequently
tested for
reinstatement after acute (21 h) food deprivation.
Experiment 2: After
heroin self-administration and extinction training, the rats
were tested for
reinstatement induced by acute food deprivation. Before the
test session,
the rats were given intracerebroventricular injections of
the CRF receptor
antagonist alpha-helical CRF ... RESULTS: Adrenalectomy had
no effect on the
extinction behavior or acute food-deprivation-induced
reinstatement of
heroin seeking. The CRF receptor antagonist, alpha-helical CRF,
dose-dependently blocked food-deprivation-induced
reinstatement. ...