cron-web.org

[A1CR]

Granted, the mice of the study (1) were mutated and lived
short lives,
transient CR led to severe difficulties. What might this
say regarding
Yo-yo or even alternate day fast CR? At this time, the
paper below is
HTML-availed only. The results in Figure 4 showed that, for
males that were
transiently CRed only, the probability of survival (%) went
from 100 at 110
days almost linearly to 0 at 123 days. For not CRed mice,
they began dying
at 122 days and all were dead by maybe five days sooner for
males than for
females, around 145 days. "In a mouse model of Alzheimer's
disease,
short-term CR decreases Aß-plaque deposition.[44][58]" and
short-term CRed
normal animals live longer. [44] is free full-text and [58]
vail in PDF.
Both are shown below.

An earlier study (2) by the say group on the same mice
mutants is
pdf-availed and described for its citation only below.

1. Hamadeh MJ, Tarnopolsky MA.
Transient caloric restriction in early adulthood hastens
disease endpoint in
male, but not female, Cu/Zn-SOD mutant G93A mice.
Muscle Nerve. 2006 Aug 29; [Epub ahead of print]

PMID: 16941656


... caloric restriction (CR) ... We previously
reported that long-term
CR improves motor performance but hastens clinical onset of
disease in an
animal model of amyotrophic lateral sclerosis (G93A mice).
G93A mice
overexpress the mutant human Cu/Zn-SOD gene and show
progressive lower motor
neuron weakness and increased oxidative stress. ...
short-term (15 days) CR
in the same animal model, we investigated the effect of
transient caloric
restriction (TCR) on paw grip endurance, clinical onset,
disease progression
(time from clinical onset to endpoint), and lifespan.
Starting at age 40
days, 32 separately caged G93A mice were randomly divided
into two groups:
ad libitum (AL, n = 17; 10 females, 7 males) and TCR (n =
15; 6 females, 9
males) with a diet equal to 60% of AL. When the TCR mice
lost 30% of their
weight they were offered food AL until endpoint, otherwise
all TCR mice were
provided food AL from age 55 days until endpoint (i.e.,
range of TCR = 13-15
days). Paw grip endurance started to decrease significantly
at age 96 days
compared with baseline values for all the groups. TCR males
reached clinical
onset 5 days sooner than TCR females. Disease progression
was 8 days faster
in TCR mice than AL mice and 6 days faster in male mice than
female mice.
The probability of survival was significantly different
between the groups,
with the TCR males having a faster rate of reaching endpoint
than TCR
females, AL males, and AL females. We conclude that TCR
hastens clinical
onset of disease and shortens the lifespan in male, but not
female, G93A
mice. Moreover, TCR hastens progress of disease but has no
effect on paw
grip endurance. The female sex is protective against the
detrimental effects
of short-term CR in G93A mice. Assuming we can extrapolate
these results to
humans, short-term CR should be avoided in patients with
amyotrophic lateral
sclerosis, especially men.

2. Hamadeh MJ, Rodriguez MC, Kaczor JJ, Tarnopolsky MA.
Caloric restriction transiently improves motor performance
but hastens
clinical onset of disease in the Cu/Zn-superoxide dismutase
mutant G93A
mouse.
Muscle Nerve. 2005 Feb;31(2):214-20.
PMID: 15625688 http://tinyurl.com/rd58m

44. Patel NV, Gordon MN, Connor KE, Good RA, Engelman RW,
Mason J, Morgan
DG, Morgan TE, Finch CE.
Caloric restriction attenuates Abeta-deposition in Alzheimer
transgenic
models.
Neurobiol Aging. 2005 Jul;26(7):995-1000. Epub 2004 Nov 25.
PMID: 15748777 http://tinyurl.com/lutcf

58. Wang J, Ho L, Qin W, Rocher AB, Seror I, Humala N,
Maniar K, Dolios G,
Wang R, Hof PR, Pasinetti GM.
Caloric restriction attenuates beta-amyloid neuropathology
in a mouse model
of Alzheimer's disease.
FASEB J. 2005 Apr;19(6):659-61. Epub 2005 Jan 13.
PMID: 15650008 http://tinyurl.com/phe2h