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[A1CR]

Fix the situation, it seems. The difference in body weights
was shown by values that were 47 g for the CRONies versus 54
g for the control mice after 16 weeks. The cumulative
calorie intakes at 22 weeks were 830 g versus 960 g,
respectively. The glucose levels averaged to
about 260 mg/dL for the control mice, 30 mg/dL higher for
the CR>CR mice and
200 mg/dL higher for the CR>ad libitum fed mice. However,
would not the
mice have had lower glucose levels if they were CRed at
later ages and not
been born from CRed mothers? These considerations may be
relevant for CRONIes
among us who do not perform as well during our CR in terms
of our blood
glucose levels. CR may keep those individuals only in the
normal glucose
range.

A previous report (2) had been presented similar data.

1. Hernandez-Valencia M, Patti ME.
A thin phenotype is protective for impaired glucose
tolerance and related to
low birth weight in mice.
Arch Med Res. 2006 Oct;37(7):813-7.
PMID: 16971218 http://tinyurl.com/r9bpv


BACKGROUND: Low birth weight is an independent risk
factor for impaired
glucose tolerance (IGT) and diabetes in adult life. This
risk extends to
both preterm and term infants, a particularly important
finding given the
increased survival of low-birth-weight infants with
improvements in neonatal
care. One potential strategy for prevention of
low-birth-weight-associated
glucose intolerance is postnatal nutritional modification
and prevention of
early postnatal weight gain. To determine the efficacy of
this approach, we
utilized our mouse model of low birth weight related to
maternal
undernutrition during the third week of pregnancy. METHODS:
We studied three
experimental groups of offspring mice: controls (C),
undernutrition with low
birth weight (UN) fed ad lib postnatally, and undernutrition
with food
restriction continued in postnatal life (UN-UN). Mean birth
weight was
significantly reduced in both groups of undernutrition
offspring in utero
(C: 1.86 +/- 0.03 vs. UN: 1.37 +/- 0.04 and UN-UN: 1.32 +/-
0.06, p <0.001).
As expected, and in accord with human data, differences in
weight between C
and UN mice disappeared by week 2 of life, indicating
catch-up growth in the
UN group. RESULTS: Body weight was similar in all groups
until 4 months of
age, after which the UN-UN group had reduced body weight as
compared with
controls (p <0.05 at 6 months). Insulin tolerance test (1
U/kg), glucose
tolerance test (2 g/kg) and glucose-stimulated insulin
secretion test (3
g/kg) at 2 months of age were identical among C, UN, and
UN-UN groups. By
age 6 months, IGT had developed in the UN mice (p <0.05 vs.
C). By contrast,
UN offspring with caloric restriction postnatally (UN-UN)
were protected
from the development of glucose intolerance, with glucose
levels identical
to that of control mice. These differences appeared to be
related to
improved insulin sensitivity in the UN-UN mice as compared
with UN mice,
although data did not reach statistical significance.
CONCLUSIONS: Our data
suggest that alterations in early postnatal nutrition are
associated with
prevention of weight gain and the development of IGT in
low-birth-weight
mice.
... Female ICR mice were mated at 6 weeks of age, and
pregnancy timed
with the appearance of a vaginal plug, indicating day 0.5 of
pregnancy.
Female mice were randomly assigned to three study groups:
(1) control group
(C), with mothers fed ad libitum during pregnancy and
suckling period, (2)
undernutrition group (UN), with 50% global restriction from
days 12.5-18.5
of gestation, but mothers and offspring fed ad libitum
during the suckling
period, and (3) undernutrition-undernutrition group (UN-UN)
with global
caloric restriction during both gestation and suckling
period. In all
groups, litter size was equalized to 8 on day 1 of life. At
weaning, male
offspring, representing at least four litters in each of the
three
experimental groups, were weaned to an ad libitum intake of
Purina 9F
standard rodent chow ...

2. PMID: 16761107 http://tinyurl.com/ejoht