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TOR pathway activation accelerates Alzheimer's in flies.....

 
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PostPosted: Thu Feb 09, 2006 2:03 am    Post subject: TOR pathway activation accelerates Alzheimer's in flies..... Reply with quote

This is an interesting finding. The TOR pathways is also thought to be activated in response to nutritional state, and so there are many interesting possibilities for this research going forward.

Many researchers have shown that, in contrast to many nutrients, amino acids get "gauged" by mTOR, the mammalian version. However, all nutrients "touch upon" mTOR, and it is thought to be operating in parallel to insulinemic signaling, as well as "downstream" of it.

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http://www.eurekalert.org/pub_releases/2006-02/cp-ffr020206.php

"Most importantly, loss of neurons could be prevented when the cell cycle was genetically blocked or when flies were fed anticancer drugs. Cell-cycle activation depended upon a hyperactive cell growth molecule, TOR (target of rapamycin), also known to be abnormally activated in Alzheimer's disease. By establishing these causal connections, this study suggests that anticancer drugs are potential therapies for Alzheimer's disease and related disorders. More broadly, the results point to an intriguing connection between cancer and dementia, two of the most important diseases in the elderly. "

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