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mTOR and PI3K: Balancing act, and Feedback loop.....

 
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PostPosted: Thu Feb 09, 2006 2:12 am    Post subject: mTOR and PI3K: Balancing act, and Feedback loop..... Reply with quote
It is well-established that mTOR produces a feedback inhibition of PI3K, which may contribute to insulin resistance in certain contexts of overnutrition. What is important to understand is that mTOR can "fully supplant" PI3K downstream effects in a "bad way", so that if you only monitor PI3K activity, you may "miss" the "bad news" that mTOR is going to put on your doorstep.

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http://cancerres.aacrjournals.org/cgi/content/abstract/66/3/1500
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mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

"The data suggest that feedback down-regulation of receptor tyrosine kinase signaling is a frequent event in tumor cells with constitutive mTOR activation. " - [Cancer Research 66, 1500-1508, February 1, 2006]

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