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Calorie Restriction with Optimum Nutrition Forum
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CRON4healthyfuture
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 Posted: Thu Feb 09, 2006 2:21 am Post subject: As Always, Bartke a must-read: Klotho, IGF-1, Dwarf mice, CR |
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You simply got to read this if you want to see the "big picture" regarding CR. If you don't have the full-text, your local health library may have it, but one of the nation's leading scientists in Basic Endocrinology yields his insights into the endocrinological substrates of longevity.
To make a long story short, CR organisms, Klotho organisms, IGF-1 mutants, and dwarf mice all share many similiarities in regards to intracellular signal transduction, similiarities that belie extracellular distinctions.
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Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging
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Click Here
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| "It was recently reported by Kurosu et al. that overexpression of Klotho, a newly discovered hormone, extends longevity of mice. Because Klotho induces IGF-1 and insulin resistance, these findings appear to contradict previous evidence for increased life span of dwarf mice with reduced IGF-1 and insulin levels and enhanced insulin sensitivity. However, activation of signaling molecules downstream from IGF-1 and insulin receptors is reduced in both Klotho and dwarf mice, suggesting common mechanisms of delayed aging. " - Trends in Endocrinology & Metabolism, Article in Press |
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