|
cron-web.org
Calorie Restriction with Optimum Nutrition Forum
|
|
|
| Author |
Message |
CRON4healthyfuture
Guest
|
 Posted: Thu Feb 09, 2006 2:33 am Post subject: FREE paper from Endocrinology: Insulin as the traffic light |
 |
|
Insulin turns off all the regulators, the "checks and balances", on your cells, and signals for uncontrolled anabolism in the context of mitgated cytoprotection.
=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=
http://endo.endojournals.org/cgi/rapidpdf/en.2005-0902v1
=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=
| Quote: |
| "In subconfluent hepatocytes insulin inhibition of IGFBP-1 mRNA levels was blocked by inhibiting PI3 kinase activation and there was a corresponding inhibition of Foxo1/Foxo3 phosphorylation. In these same cells inhibition of the insulin effect by rapamycin occurred in the presence of insulin induced Foxo1/Foxo3 phosphorylation. In confluent hepatocytes insulin could not activate the PI3 kinase - Akt - Foxo1/Foxo3 pathway but still inhibited IGFBP-1 gene expression in an mTOR dependent manner." - Endocrinology |
=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-= |
|
| Back to top |
|
 |
|
|
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum
|
|
|
Powered by phpBB © 2001, 2005 phpBB Group
|
Search
Log in
