cron-web.org

[A1CR]

It seems that the paper below provides only a summary of
previous data.

Lee GD, Wilson MA, Zhu M, Wolkow CA, de Cabo R, Ingram DK,
Zou S.
Dietary deprivation extends lifespan in Caenorhabditis elegans.
Aging Cell. 2006 Nov 10; [Epub ahead of print]
PMID: 17096674

Dietary restriction (DR) is well known as a nongenetic
intervention that
robustly extends lifespan in a variety of species; however,
its underlying
mechanisms remain unclear. We have found in Caenorhabditis
elegans that
dietary deprivation (DD) during adulthood, defined as
removal of their food
source Escherichia coli after the completion of larval
development,
increased lifespan and enhanced thermotolerance and
resistance to oxidative
stress. DD-induced longevity was independent of one C.
elegans SIRTUIN,
sir-2.1, which is required for the effects of DR, and was
independent of the
daf-2/insulin-like signaling pathway that independently
regulates longevity
and larval diapause in C. elegans. DD did not significantly
alter lifespan
of fem-1(hc17); eat-2(ad465) worms, a genetic model of DR.
These findings
suggest that DD and DR share some downstream effectors. In
addition, DD was
detrimental for longevity when imposed on reproductively
active young
adults, suggesting that DD may only be beneficial in the
absence of
competing metabolic demands, such as fertility. Adult-onset
DD offers a new
paradigm for investigating dietary regulation of longevity
in C. elegans.
This study presents the first evidence that long-term DD,
instead of being
detrimental, can extend lifespan of a multicellular adult
organism.