cron-web.org

[A1CR]

A prominent figure in CR http://tinyurl.com/yxx8r4
http://tinyurl.com/yxv8t3
died from
http://en.wikipedia.org/wiki/Amyotrophic_lateral_sclerosis
in April 2004 and a
new concept has been forwarded regarding the association of
CR with the
disease. It may have been that Roy's brain may have
suffered from his
inability to respond due to the http://tinyurl.com/yd4czo
stress response.


Mattson MP, Cutler RG, Camandola S.
Energy intake and amyotrophic lateral sclerosis.
Neuromolecular Med. 2007;9(1):17-20.
PMID: 17114821

Roy Walford, a physician and scientist who pioneered
research on the
anti-aging effects of caloric restriction and subjected
himself to a
low-energy diet, recently died from amyotrophic lateral
sclerosis (ALS).
Information from his case, epidemiological findings, and
recent controlled
studies in mouse models of ALS suggest that low-energy diets
might render
motor neurons vulnerable to degeneration, whereas
high-energy diets are
ameliorative. This contrasts with the effects of low-energy
diets on various
neuronal populations in the brain that respond adaptively,
activating
pathways that promote plasticity and resistance to disease.
One reason that
motor neurons might be selectively vulnerable to low-energy
diets is that
they are unable to engage neuroprotective responses to
energetic stress
response involving the protein chaperones, such as,
heat-shock protein-70.