cron-web.org

[A1CR]

It appears that, maybe, our increased serotonin-associated
http://en.wikipedia.org/wiki/5-hydroxytryptamine level when
we CR is a
mental and long life plus.

Navarro A, Sanchez-Pino MJ, Gomez C, Bandez MJ, Cadenas E,
Boveris A.
Dietary thioproline decreases spontaneous food intake and
increases survival
and neurological function in mice.
Antioxid Redox Signal. 2007 Jan;9(1):131-41.
PMID: 17115892

Male mice on a diet supplemented with thioproline
(l-thiazolidine-4-carboxylic acid), a physiological
metabolite of
5-hydroxytryptamine, at 2.0 g/kg of food from 28 weeks of
age and for their
entire life, showed a 23-29% increased median and maximal
life span. These
survival increases were associated with improved
neurological functions.
Compared to control mice, thioproline-supplemented mice had
a 20% lower
integral spontaneous food intake, and 10% lower body weight
at 100 weeks of
age. Body weight showed a statistically significant inverse
relationship
with survival and neurological performances.
Thioproline-supplemented mice
exhibited a 58-70% decrease of the age-dependent oxidative
damage in brain
and liver mitochondria at 52 weeks (old mice) and 78 weeks
(senescent mice)
of age, respectively. The age-associated decrease of brain
mitochondrial
enzyme activities, NADH-dehydrogenase, cytochrome c oxidase,
and
mitochondrial nitric oxide synthase (mtNOS), in old and
senescent mice were
markedly prevented (51-74%) by thioproline. In vitro,
thioproline neither
exhibited direct antioxidant activity nor had any effect on
the electron
transfer or mtNOS functional activities of brain and liver
mitochondria. It
is surmised that thioproline induces an anorexic effect
associated with
improved survival and neurological function through a
decreased oxidative
damage and regulation that may involve hypothalamic appetite
centers.

[A1CR]

It appears that, maybe, our increased serotonin-associated
http://en.wikipedia.org/wiki/5-hydroxytryptamine level when
we CR is a
mental and long life plus.

Navarro A, Sanchez-Pino MJ, Gomez C, Bandez MJ, Cadenas E,
Boveris A.
Dietary thioproline decreases spontaneous food intake and
increases survival
and neurological function in mice.
Antioxid Redox Signal. 2007 Jan;9(1):131-41.
PMID: 17115892

Male mice on a diet supplemented with thioproline
(l-thiazolidine-4-carboxylic acid), a physiological
metabolite of
5-hydroxytryptamine, at 2.0 g/kg of food from 28 weeks of
age and for their
entire life, showed a 23-29% increased median and maximal
life span. These
survival increases were associated with improved
neurological functions.
Compared to control mice, thioproline-supplemented mice had
a 20% lower
integral spontaneous food intake, and 10% lower body weight
at 100 weeks of
age. Body weight showed a statistically significant inverse
relationship
with survival and neurological performances.
Thioproline-supplemented mice
exhibited a 58-70% decrease of the age-dependent oxidative
damage in brain
and liver mitochondria at 52 weeks (old mice) and 78 weeks
(senescent mice)
of age, respectively. The age-associated decrease of brain
mitochondrial
enzyme activities, NADH-dehydrogenase, cytochrome c oxidase,
and
mitochondrial nitric oxide synthase (mtNOS), in old and
senescent mice were
markedly prevented (51-74%) by thioproline. In vitro,
thioproline neither
exhibited direct antioxidant activity nor had any effect on
the electron
transfer or mtNOS functional activities of brain and liver
mitochondria. It
is surmised that thioproline induces an anorexic effect
associated with
improved survival and neurological function through a
decreased oxidative
damage and regulation that may involve hypothalamic appetite
centers.