cron-web.org

[A1CR]

The paper below details may be of our interest regarding
this sirtuin, which is thought to
be involved in the workings of CR, acts.

Anastasiou D, Krek W.
SIRT1: Linking Adaptive Cellular Responses to
Aging-Associated Changes in
Organismal Physiology.
Physiology (Bethesda). 2006 Dec;21(6):404-410.
PMID: 17119153

Sirtuins comprise a family of enzymes implicated in the
determination of
organismal life span in yeast and the nematode. The
mammalian sirtuin SIRT1
has been shown to deacetylate several proteins in an
NAD(+)-dependent
manner. SIRT1 substrates are involved in the regulation of
apoptosis/cell
survival, endocrine signaling, differentiation, chromatin
remodeling, and
transcription. Thus SIRT1 provides a molecular link between
nutrient
availability and adaptive transcriptional responses. This
review presents
current evidence as to how SIRT1 functions are relevant to
changes in tissue
physiology that occur with ageing and its implications for
future
pharmacological intervention to alleviate such degenerative
processes.