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This March 23, 2004 article by CRON4healthyfuture points to a newly published study by Spindler showing that in mice, relatively late onset CR (human equivalent of 60-65) works well to extend lifespan, and elicit rapid changes in DNA expression that resemble those in younger mice subject to long-term CR. This seems very encouraging for people choosing to start CR in adulthood.


The Associated Press article gives some interesting specifics from
Spindler's finding that late-onset CR provides significant
benefits....

Heh, and I thought his liver enzyme studies were not going to pan out
in terms of lifespan in old mice. But he trusted his intuition and
hit the jackpot.

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http://story.news.yahoo.com/news?tmpl=story&cid=534&ncid=534&e=4&u=/ap/20040
323/ap_on_he_me/fit_eat_less_live_long
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"The study, appearing this week in the Proceedings of the National
Academy of Sciences (news - web sites), showed that mice at the
relatively advanced age of 19 months that were placed on a restricted
calorie diet lived 42 percent longer than litter mates who continued
to eat a standard diet."

"Stephen R. Spindler of the University of California, Riverside,
leader of a team conducting the research, said there is little
evidence yet that dietary restrictions will extend human life, but in
mice, at least, sensible eating even at older ages clearly has a
longevity benefit. He said a 19-month-old mouse is the age equivalent
of 60 to 65 years in humans."

"Spindler said old mice placed on a restricted calorie diet responded
quickly with better health and that eventually the animals lived up
to six months longer than litter mates fed the standard diet. "

"Spindler said that while older mice that go on a diet do live longer
than those that don't, they still don't live as long as mice that
have been on restricted diets for a lifetime. He said mice put on
low-calorie diets just after birth have been known to live up to four
years, almost twice as long as normal mice and months longer than the
aged mice in the new study."

'"The dogma has always been that the earlier in life you start a
restricted diet, the better it works for extending life," said Roth,
a researcher studying the aging process who was not involved in
Spindler's research. "This finding suggests that you may get some of
the same benefits starting late in life."'

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http://www.betterhumans.com/News/news.aspx?articleID=2004-03-22-3
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"Further, DNA microarray analysis of old control mice switched to a
calorie-restricted diet for two, four and eight weeks showed a rapid
shift toward the gene expression profile of mice on a long-term
calorie-restricted diet. "

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