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[CRON4healthyfuture]

These researchers are presenting an experimental model where a high-salt diet dose-dependently increased the development of gastric cancers in everyone's favorite pet, the Mongolian Gerbil.

What is interesting is that they suggest that the high-salt diet causes surface mucous cells to increase their mucus production, while simultaneously causing "gland mucous cells", which are buried deeper in the mucosa, to decrease their mucus production. Apparently H. pylori does not like the gland mucin but likes the surface mucus, so this transition promotes H. pylori colonization.

Because H. pylori attracts the ire of the immune system, it is thought to increase chronic inflammation and eventually lead to cancer. Through this high-salt transition of mucus production, it is thought that H. pyloric colonization is facilitated and thus gastric cancer is promoted.

Curiously, simply squirting salt water into the little buggers did not cause gastric cancer, thus emphasizing the putative role being played by H. pyloric colonization in gastric carcinogenesis.

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